Biology Reference
In-Depth Information
Setdb1/
ESET/
KMT1E,
Setdb2/
KMT1F
Embryo:
Setdb1
KO is
lethal around E3.5-E5.5
and shows ICM growth
defects. No KO mice
reported for
Setdb2
(
Dodge, Kang, Beppu,
Lei, & Li, 2004
).
ESC: Setdb1 is
involved in
transcriptional repression
of euchromatic genes
and repeats; required for
maintenance of
pluripotency (
Bilodeau,
Kagey, Frampton, Rahl,
& Young, 2009; Dodge
et al., 2004; Lohmann
et al., 2010; Matsui et al.,
2010
).
dSetdb1
Homozygous lethal.
Localized at
euchromatin and on
chromosome 4 (
Seum,
Bontron, Reo, Delattre,
& Spierer, 2007
).
HP1a/
Cbx5,
HP1b/
Cbx1,
HP1g/Cbx3
Embryo:
HP1b
KO is
perinatal lethal and
leads to genomic
instability.
HP1g
KO
mice are infertile and
show impaired
spermatogenesis, cell
cycle and meiosis defects.
No
HP1a
KO mice have
been reported (
Abe et al.,
2011; Aucott et al., 2008;
Brown et al., 2010;
Naruse, Fukusumi,
Kakiuchi, &Asano, 2007;
Takada et al., 2011
).
ESC: Modest
upregulation of ERV
(
Maksakova et al., 2011
).
Su(var)
2-5/
HP1a
Flies have at least five
HP1 homologues
(HP1a/b/c/d/e), see
text for detail.
HP1a
KO
flies die at 3rd instar larva
(
Eissenberg, Morris,
Reuter, & Hartnett,
1992; Kellum, Raff, &
Alberts, 1995
).
LHP1/
TLF2
Function with PRC1, see
Table 8.3
and text for
details (
Gaudin et al.,
2001; Turck et al., 2007
).
a
In plants,
SUVR4
has been suggested to be most closely related to
G9a.
