Biology Reference
In-Depth Information
Suv4-20H1/2
SET
Catalyzes
H4K20me2/
3
Heterochromatin Embryo
(full KO)
Perinatal lethality
Schotta et al.
(2004)
MEFs
(conditional
KO)
Increase in DNA damage
sensitivity
Schotta et al.
(2008)
Cell cycle defects and
chromosomal aberrations
EED
WD repeats
Protein-
protein
interactions
and assembly
Embryo
(full KO)
Problems with
gastrulation leading to
lethality
Shumacher,
Faust, and
Magnuson (1996)
Loss of maintenance of
the inactive state of the X
chromosome in
trophoblast cells
Wang et al.
(2001)
E(z)h2
SET
Catalyzes
H3K27me3
Embryo
(full KO)
Embryonic lethality
caused by problems by
implantation, gastrulation
and growth defects
O'Carroll et al.
(2001)
Germ line
(conditional
KO)
No effect due to a rescue
of the phenotype
probably caused by the
paternal allele
Erhardt et al.
(2003)
Suz12
Zinc finger
domain
Embryo
(full KO)
Lethality around E8.5
with similar phenotype to
Eed and E(z)h
Pasini, Bracken,
Jensen, Lazzerini
Denchi, and
Helin (2004)
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