Biology Reference
In-Depth Information
A
Polycomb and trithorax complexes
Fruit fly
(
Drosophila melanogaster
)
PRC1 complex
PRC2 complex
PhoRC complex
COMPASS-like complex
Nurf55/p55
PCL
Menin
HCF1
RING
PH
E(z)
Su(z)12
dSFMBT
DPY30
TRX
RBBP5
PSC
ESC
WD5
ASH2
PC
PHO
Mouse
(
Mus musculus
)
COMPASS-like complex
PRC2 complex
PRC1 complex
RYBP-PRC1 complex
MOF
Menin
HCF1
RING1B
PHC1-3
RING1B
EZH1/2
SUZ12
DPY30
MLL1/2
RBBP5
BMI1/MEL18
MEL18
EED
WDR5
ASH2L
CBX2-8
RYBP
B
Distribution of histone marks and PC
Fruit fly
(
Drosophila melanogaster
)
max
0
max
0
Abd-B
abd-A
Ubx
~ 10 mb
Antp
Scr
Dfd
pb
lab
Mouse
(
Mus musculus
)
E10.5 anterior trunk (partially active)
E10.5 forebrain (inactive)
max
max
0
0
max
max
0
0
Hoxd13
Hoxd9
Hoxd4
Hoxd1
Hoxd13
Hoxd9
Hoxd4
Hoxd1
Figure 4.5 Polycomb and Trithorax complexes and the distribution of modified his-
tones on Hox clusters. (A) Polycomb (left) and Trithorax (right) complexes in Drosophila
and mouse with described associations in Hox gene regulation. (B) Top: Distribution of
the repressive H3K27me3 histone mark and PC (Polycomb) over BX-C and ANT-C in 4
-
12 h Drosophila embryos. Bottom: Distribution of repressive H3K27me3 and activating
H3K4me3 marks on the HoxD cluster in the forebrain and the anterior part of the trunk
in E10.5 mouse embryos. The anterior trunk sample is a dissection of the most dorsal
part of the embryo, where most cells express the Hoxd1
8 genes, following spatial
collinearity. Panel (A) compiled from
Bantignies and Cavalli (2011)
,
Mohan, Lin, Guest,
and Shilatifard (2010)
,
Sawarkar and Paro (2010)
,
Schuettengruber, Chourrout,
Vervoort, Leblanc, and Cavalli (2007)
,
Schuettengruber, Martinez, Iovino, and Cavalli
(2011)
,
Schwartz and Pirrotta (2007, 2008)
,and
Tavares et al. (2012)
. Panels (B, top)
ChIP-on-chip data from
Schuettengruber et al. (2009)
and (B, bottom) ChIP-seq data from
Noordermeer et al. (2011)
.
-
