Age-Related Changes in Whole-Bone Structure and Strength - Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology - page 20

Table 5 Vertebral changes—lumbar spine

% Change per decade*

Authors Materials Method Study

design

Bone Sex TA Tot.vBMD Trab.vBMD

Mosekilde & Mosekilde
[ 55 ]

44 donors (27 female, 17 male)
15-87 years

Physical
measurement

CS L2 Vertebra Pooled 2.9 - -

a

Ebbesen et al. [ 53 ] 101 donors (51 female, 50 male)

18-96 years

QCT CS L3 Vertebra Female - - -19

Male - - -15

b c

Duan et al. [ 68 ] 719 donors (477 female, 242 DXA CS L3 Vertebra Female 0.9 -11.6 -

male)
18-92 years

Male 2.3 -4.3 -

d

Riggs et al. [ 50 ] 696 subjects (373 female, 323

male)
20-97 years

QCT CS L1-L3

Vertebra

Female 1.9 -12.2 -10.9

Male 1.9 -7.6 -9.7

Sigurdsson et al. [ 8 ] 1715 subjects (908 female, 807

male)
67-93 years

QCT CS L1-L2

Vertebra

Female 4.7 -13.3 -25.1

Male 6.0 -6.3 -14.9

TA, total (subperiosteal) area; Tot.vBMD, avg. bone mineral density of total volume; Trab.vBMD, average bone mineral density of trabecular volume
All results based on cross-sectional (CS) study design
*Percent change calculated using slope of regression line (e.g, TA vs. age), multiplied by 10 and divided by overall mean (unless noted otherwise)
Slopes are taken from papers (if reported), or determined by linear regression from data presented in papers
(NS) regression is not statistically significant, p [ 0.05
a

estimated from Fig. 3 of paper

b

includes young and elderly groups, not fracture groups

c

authors estimated CSA and vBMD values from two DXA projections; change based on two-point slope from data in their Table 1

d

from Table 1 of paper, recalculated based on estd. overall means