Age-Related Changes in Whole-Bone Structure and Strength - Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology - page 15

Table 3 Metaphyseal changes—lower extremity

% Change per decade*

Authors Materials Method Study design Bone Sex TA MA CA Tot.vBMD Trab.vBMD

a

Russo et al. [ 6 ] 1205 subjects

(693 female,
512 male)
20-102 years

pQCT CS Distal Tibia Female 0.8 - - -4.9 -4.6

Male 1.8 - - -0.7 -2.9

b

Riggs et al. [ 50 ] 696 subjects

(373 female,
323 male)
20-97 years

pQCT CS Distal Tibia Female 0.3 (NS) 0.9 -2.3 -5.3 -4.0

Male 0.6 (NS) 0.9 (NS) -0.3 -3.6 -4.5

c

Lauretani et al. [ 3 ] 809 subjects

(464 female,
345 male)
21-102 years

pQCT CS, LNG Distal Tibia Female - - - -5.0 -3.7

Male - - - -2.9 -3.3

a, d

Yuen et al. [ 9 ] 1258 subjects

(638 female,
620 male)
20-98 years

pQCT CS Distal Tibia Female 0.7 1.8 - - -6.4

Male 0.8 2.7 - - -6.0

c e

Macdonald et al. [ 51 ] 644 subjects

(442 female,
202 male)
20-99 years

HR-pQCT CS Distal Tibia Female 1.1 - -3.5 -6.5 -2.8

e

Male 0.9 - -1.3 -3.4 -2.3

a f g h i

Duan et al. [ 67 ] 1196 subjects

(801 female,
395 male)
18-92 years

DXA CS Femoral Neck Female 0.5 1.5 -5.6 -6.2 -

f g h i

Male 1.9 2.7 -4.2 -5.0 -

b

Riggs et al. [ 50 ] 696 subjects

(373 female,
323 male)

QCT CS Femoral Neck Female 1.8 3.8 -2.3 -8.9 -11.7

Male 1.0 2.2 -4.0 -6.0 -8.5