The Effect of Aging on Skeletal Mechanoresponsiveness: Animal Studies - Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology - page 201

Table 3 (continued)

Study Animal sex,

species (Strain)

Age Protocol Significant observations regarding

the influence of loading

Conclusion

Brodt and
Silva
[ 57 ]

Male, mice
(BALB/c)

7 months—mature
22 months—old

Tibial axial compression, 1 week,
60 cycles/day, 900-1900 le
endocortical, 1400-3100 le
periosteal,
0.5 s load ? 10 s rest

Endocortical bone formation: M :,
O ::
Periosteal bone formation: M :,O:
Dose-response for both M, O

Modest age effect;
old more
responsive
(endocortical)

Silva et al.
[ 58 ]

Female, mice
(BALB/c)

2, 4 months—
young
7 months—mature
12 months—
middle age

Tibial axial compression, 6 weeks,
60 cycles/day, 1300 le endocortical,
2400 le periosteal, 0.5 s load ? 10 s
rest

Cortical bone volume: Y :,M:,MA:
Trabecular bone volume: M;,MA;

Modest age effect;
young more
responsive

Lynch et al.
[ 59 , 60 ]

Age effect;
young more
responsive
: Increases in response to loading, :: Relatively larger increases in response to loading, ; Decreases in response to loading; Y Young, M Mature, MA Middle
Age, O Old. Strains are periosteal strains unless noted otherwise
a

Female, mice
(C57Bl/6)

2 months—young
6 months—mature

Tibial axial compression, 2 weeks, 1200
cycles/day, 1200-2200 le,4Hz

Cortical bone area, mom. inertia:
Y :,M:
Trabecular bone volume: Y ::,M:

Described in discussion only