The Effect of Aging on Skeletal Mechanoresponsiveness: Animal Studies - Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology - page 194

Table 2 Summary of studies that examined the influence of age on bone responses to intrinsic loading

Study Animal sex,

species (strain)

Age Protocol Significant observations regarding

the influence of loading

Conclusion

Raab et al.
[ 29 ]

Female, rat
(Fisher 344)

2.5 months—
young
25 months—old

Treadmill running, 10 weeks,
60 min/day, 5 days/week,
15 deg incl.
Young—36 m/min, Old—
15 m/min

Fat free weight: Femur—Y:,O:
Ultimate force: Femur—Y:,O:,
Humerus—Y:,O:
Yield force: Humerus—Y:,O:

No age effect

Leppanen
et al.
[ 30 ]

Female, rat
(Sprague-
Dawley)

11 months—mature (FM)
22 months—old (FO)

Treadmill running, 14 weeks
30 min/day, 30 inclination

Ultimate Force: Femur—FO:,
Femoral neck—FO:,MO:
Cross-sectional area: Femur—
MM:, Femoral neck—FO:,
MO:
BMC: Femoral neck—FO:,MO:

No age effect

Male, Rat
(Sprague-
Dawley)

11 months—mature (MM)
19 months—old (MO)

Bennell
et al.
[ 31 ]

Female, Rat
(Sprague-
Dawley)

1 months—young
4 months—immature

Treadmill running, 12 weeks
60-70 min/day, 5 days/
week, 26 m/min

Ultimate force: Tibia—Y:,IM:
Cross-sectional area: Tibia—Y:,
IM:
Histomorphometric indices:
Tibia—Y:,IM:
BMC: Lumbar (L1-L4)—Y:,IM:

No age effect

Umemura
et al.
[ 32 ]

Female, Rat
(Fisher 344)

3 months, 6 months—
young
12 months—mature
20 months,
27 months—old

Treadmill running, 8 weeks
60 min/day, 5 days/week,
30 m/min

Fat free weight: Tibia—Y,M :;
Femur—Y:
Diameter: Femur—Y:

Age effect; old not
responsive

Jump training, 8 weeks
100 times/day, 5 days/week,
40 cm (up)

Fat free weight: Tibia—All:;
Femur—Y:,O:
Diameter: Femur—Y:,
Tibia—All:

Modest age effect;
old less
responsive

Jarvinen
et al.
[ 33 ]

Male, Rat
(Sprague-
Dawley)

1 months—young
8 months—mature

Treadmill running, 14 weeks
10 min/day, 4 days/week,
18 m/min, 30 inclination

Femur [ 1 ]
Ultimate force: Y:,M:
Cross-sectional area: Y:
BMC: Y:,M:

No age effect