Biology Reference
In-Depth Information
Figure 20.2.
Schematics of normal (healthy) and abnormal cancer cell division
showing genetic aberrations and novel techniques to identify cancer-related changes
in cells.
for
Additionally,
quantiication of cancer cell physiology is required for customization of
drug therapies based on speciic characteristics and extent of abnormality
of cancer cell populations as well as the response of cancer cell populations
to therapies. Cancer diagnosis has been widely and aggressively pursued by
various nanotechnology research initiatives. In particular, this chapter will
highlight some recent AFM techniques developed for cancer diagnostics
based on unique nanoscale properties and/or structure of cancer cells or
tumour-associated biomolecules.
developing novel approaches for early cancer detection
.
20.2.1 Cellular Nanomechanics: Using AFM for Cancer Detecon
Conventionally, detection of cancerous cells is based on morphological
analysis though it is realized that diagnosis based on morphological
examination can be dificult,
6
with cyto-morphological analysis alone
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