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Figure 6.20.
Schematic model of nuclear pore structural disruption during
apoptosis.
All in all, apoptosis requires a remodelling of structure and mechanics
Degradation of the cytoplasmic NPC ilaments as well as the nuclear basket
deprives the NPC of its transport selectivity and thus leads to disruption of
selective nucleocytoplasmic cross-talk. This in turn promotes the exchange
of apoptotic factors between the cytosol and the nucleus. Simultaneous
degradation of the nuclear lamina cuts off the cross-talk between the
chromatin and the nuclear envelope and leads to a destabilisation of the cell
nucleus, ultimately promoting nuclear collapse.
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