Biomedical Engineering Reference
In-Depth Information
of-concepts, it is better to look into these issues early at the bench in order for a
successful nanocarrier to move forward quickly.
3.5 Conclusion
The challenge to develop truly translational nanocarriers and nanomedicine is
to use excipientable materials and processes of scale-up ability to produce
nanocarriers with optimal 2R2S capability. While research aimed at proof-of-
concepts remains important, it is important to increasingly focus on
comprehensive approaches or systems that include all the three key elements
as early as possible in the innovation chain, to speed up developments of
translational nanomedicine.
d n 4 y 3 n g | 2
References
1. R. Tong, D. A. Christian, L. Tang, H. Cabral, J. R. Baker, Jr.,
K. Kataoka, D. E. Discher and J. Cheng, MRS Bull., 2009, 34, 422-431.
2. F. Danhier, O. Feron and V. Preat, J. Controlled Release, 2010, 148, 135-
146.
3. M. E. R. O'Brien, N. Wigler, M. Inbar, R. Rosso, E. Grischke,
A. Santoro, R. Catane, D. G. Kieback, P. Tomczak, S. P. Ackland,
F. Orlandi, L. Mellars, L. Alland, C. Tendler and C. B. C. S. Grp, Ann.
Oncol., 2004, 15, 440-449.
4. W. J. Gradishar, S. Tjulandin, N. Davidson, H. Shaw, N. Desai, P. Bhar,
M. Hawkins and J. O'Shaughnessy, J. Clin. Oncol., 2005, 23, 7794-7803.
5. V. P. Torchilin, Eur. J. Pharm. Sci., 2000, 11, S81-S91.
6. H. Maeda, J. Wu, T. Sawa, Y. Matsumura and K. Hori, J. Controlled
Release, 2000, 65, 271-284.
7. C. Wong, T. Stylianopoulos, J. Cui, J. Martin, V. P. Chauhan, W. Jiang,
Z. Popovic, R. K. Jain, M. G. Bawendi and D. Fukumura, Proc. Natl.
Acad. Sci. U. S. A., 2011, 108, 2426-2431.
8. Q. Sun, M. Radosz and Y. Shen, J. Controlled Release, 2012, 164, 156-
169.
9. M. Ye, S. Kim and K. Park, J. Controlled Release, 2010, 146, 241-260.
10. F. Mohamed and C. F. van der Walle, J. Pharm. Sci., 2008, 97, 71-87.
11. D. Peer, J. M. Karp, S. Hong, O. C. FaroKhzad, R. Margalit and
R. Langer, Nat. Nanotechnol., 2007, 2, 751-760.
12. G. Shazly, T. Nawroth and P. Langguth, Dissol. Techn., 2008, 15, 7-10.
13. B. Narasimhan and R. Langer, J. Controlled Release, 1997, 47, 13-20.
14. Z. L. Tyrrell, Y. Shen and M. Radosz, Prog. Polym. Sci., 2010, 35, 1128-
1143.
15. C. O. Rangel-Yagui, A. Pessoa and L. C. Tavares, J. Pharm. Pharm. Sci.,
2005, 8, 147-163.
16. Y. Shen, Y. Zhan, J. Tang, P. Xu, P. A. Johnson, M. Radosz, E. A. Van
Kirk and W. J. Murdoch, AIChE J., 2008, 54, 2979-2989.
 
Search WWH ::




Custom Search