Biomedical Engineering Reference
In-Depth Information
a given tumor will respond to a single therapeutic agent. Moreover, solid
tumors are known to have a highly heterogeneous population of different cell
types. Despite tremendous advances in tumor targeting strategies, many
scientific, technological, and clinical challenges remain that will require a
highly interdisciplinary and collaborative approach to overcome. Further
studies are critically important to understand the systemic delivery of targeted
nanomedicines in the context of complex tumor pathophysiology. Although
we are still far from Paul Ehrlich's prediction of a ''magic bullet'', with
advances in cancer biology and explosive developments in materials science
and imaging technology, it is feasible that we can break through the current
threshold and enter a new era of personalized nanomedicines for combined
cancer diagnosis and therapy.
d
n
4
y
3
n
g
|
0
Acknowledgements
This work is supported by the National Institutes of Health (RO1 EB013149,
RO1CA129011),
the
Cancer
Prevention
Research
Institute
of
Texas
(RP120897, RP120094), and the Texas FUSION fund.
References
1. R. Siegel, D. Naishadham and A. Jemal, Ca-Cancer J. Clin., 2012, 62, 10-
29.
2. V. T. DeVita and S. A. Rosenberg, New Engl. J. Med., 2012, 366, 2207-
2214.
3. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu and M. J. Thun, Ca-
Cancer J. Clin, 2009, 59, 225-249.
4. D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit and
R. Langer, Nat. Nanotechnol., 2007, 2, 751-760.
5. B. Sumer and J. Gao, Nanomedicine (London, U. K.), 2008, 3, 137-140.
6. M. E. Davis, Z. Chen and D. M. Shin, Nat. Rev. Drug Discovery, 2008, 7,
771-782.
7. D. Sutton, N. Nasongkla, E. Blanco and J. Gao, Pharm. Res., 2007, 24,
1029-1046.
8. E. Blanco, C. W. Kessinger, B. D. Sumer and J. Gao, Exp. Biol. Med.,
2009, 234, 123-131.
9. E. Blanco, E. A. Bey, C. Khemtong, S.-G. Yang, J. Setti-Guthi, H. Chen,
C. W. Kessinger, K. A. Carnevale, W. G. Bornmann, D. A. Boothman
and J. Gao, Cancer Res., 2010, 70, 3896-3904.
10. Y. Matsumura and H. Maeda, Cancer Res., 1986, 46, 6387-6392.
11. V. Torchilin, Adv. Drug Delivery Rev., 2011, 63, 131-135.
12. F. Yuan, M. Leunig, S. K. Huang, D. A. Berk, D. Papahadjopoulos and
R. K. Jain, Cancer Res., 1994, 54, 3352-3356.
