Biomedical Engineering Reference
In-Depth Information
d
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y
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Figure 13.22
Cumulative paclitaxel release from a diblock, PEG-b-(PDLLA-co-
PCL) [5k-b-(2k-co-3k)], and two triblocks, PEG-b-PDLLA-b-PCL
(5k-b-1.5k-b-1.5k) and PEG-b-PLLA-b-PCL (5k-b-1.5k-b-1.5k), in
distilled water at pH 5 7.4 and T 5 37 uC. (Reproduced from
Tyrrell et al.
21
with permission from the American Chemical Society.)
extend this method to other polymer-drug formulations? How to scale-up
NCM safely to kilogram or more product quantities? How to achieve a
consistently uniform product quality necessary for FDA approvals?
Drug loading and efficiency of diblock and triblock copolymers.
a
Table 13.1
Loading
content
Encapsulation
efficiency
Overall loading
efficiency
Polymer
MW
PEG-b-PCL
5k-5k
12.4%
82.1%
87.0%
PEG-b-(PDLLA-co-
PCL)
5k-(2k-co-3k)
10.5%
100.0%
80.2%
PEG-b-PDLLA-b-PCL
5k-1.5k-1.5k
10.9%
106.0%
72.3%
PEG-b-PLLA-b-PCL
5k-1.5k-1.5k
10.4%
98.6%
77.1%
a
Data shown taken from work by Tyrrell et al.
20,21
