Biomedical Engineering Reference
In-Depth Information
Table 12.1
(Continued)
Targeting drug delivery system
Advantages
Disadvantages
Ref.
96-99
Surface-modified
delivery system
Antibody-conjugated
delivery system
1. Has high selectivity and specificity
for tumor site.
1. The receptor may be expressed
on normal cells and may cause
side effects.
2. Low ligand conjugation
efficiency.
3. The different expression level
of antigen/receptors on
different tumor cells may
decrease the site-specific
targeting.
100-103
Ligand-conjugated
delivery system
104-108
Other carriers
Magnetically targeted drug
carrier
1. Magnetic fields are focused over the
target site and allow the particles to
be captured at the target sites.
1. Only effective for tumor sites
close to the body's surface;
sites deeper within the body
are difficult to target.
83,109
Cell-based drug
carriers
Immune cells
[macrophages, T cells,
natural killer (NK) cells]
1. Could enhance the tumor site target
efficiency and improve the
therapeutic effect.
2. Have tumoricidal activity.
1. Difficulty in obtaining
sufficient numbers.
2. Not easy to transduce these
cells with the plasmids.
3. Suffer from the
immunosuppressive nature of
many tumors.
9-11
Mesenchymal stem cells
(MSCs)
1. Easily available and to expand by
simple propagation procedures.
2. Have high migration potential to the
tumor sites.
3. Have a low immunogenicity and
intrinsic mutation rate.
4. Do not possess neurotoxicity or
tumorigenicity.
1. The vectors and cytokines
used are limited
2. Little is understood about the
fate of MSCs in vivo.
 
Search WWH ::




Custom Search