Biomedical Engineering Reference
In-Depth Information
d
n
4
y
3
n
g
|
5
Figure 11.7
(A) Synthesis and acid-catalyzed hydrolysis of PCurc 8. (B) Cytotoxicity
of PCurc 8 to SKOV-3, OVCAR-3, and MCF-7 cancer cell lines. (C) In
vivo
antitumor
activity
of
Curc-OEG
against
SKOV-3
carcinoma
xenografts. (Adapted from Tang et al.
65
)
(Figure 11.8A).
67
The polymers had good water solubility and high and fixed
platinum-loading contents, 27.7% for P(DSP-EDA) and 29.6% for P(DSP-
PA), respectively, which were not achievable by any conventional conjugation
methods. Additionally, the biodistribution results suggested that the con-
jugated platinum polymer might greatly minimize the liver and renal toxicity
(Figure 11.8B).
67
11.4 Future Challenges
Although polymer-drug conjugates or prodrugs have been investigated for
several decades, the number of approved polymer-based prodrugs is still
small.
68
Thus, the design of polymer-based prodrugs with more efficient drug
delivery to achieve higher therapeutic efficacy is still a pressing need. Three
aspects should be taken into consideration when designing a new prodrug:
