Biomedical Engineering Reference
In-Depth Information
4.8 Conclusion
In summary, although intensive studies have been made on nonviral gene
vectors and numerous research papers have been published in recent years,
their commercial development and clinical applications are still limited.
Therefore, great emphasis should be placed on in vivo trials and development
of new commercial transfection agents during the next decade. In order to
obtain the permission for clinical application of nonviral gene vector-mediated
gene therapy, sustained efforts should be made to combine those efficient
synthetic vectors with therapeutic genes, make clinical safety assessments, and
provide indications how animal models correlate with clinical experience. It is
very important for us to remember the mechanisms, applications, and
limitations of current gene delivery systems, and obtain more novel
information from chemical, medical, biological, and various other fields so
as to design innovational successful gene vectors. Gene therapy has rapidly
developed, and it will play an important role in future medical research and
clinical applications. It is possible to predict that every genetic disease will have
gene therapy as its treatment in the future.
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Acknowledgements
This
work
was
financially
supported
by
the
Ministry
of
Science
and
Technology
of
China
(2009CB930300,
2011CB606202)
and
the
Natural
Science Foundation of Hubei Province, China (2009CDA024).
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