Biomedical Engineering Reference
In-Depth Information
Figure 12.2
The organization of the UGT1A locus is depicted (not drawn to scale). Individual first exons are positioned at the 5
′
′
end of the chromosome and common exons 2-5 are positioned at the 3
RNA
polymerase II core promoter is shown. A TATA box (TATAA) is located at -28 from the transcription start site (TSS), and
a downstream core promoter element (DPE) with an AGTCC is found at +26 from the TSS. A dinucleotide polymorphism
of A(TA)
end. The DNA sequence of the
UGT1A1
TAA in the TATA box is common in all ethnic populations, with A(TA)
TAA as the major allele.
5-8
6
