Biomedical Engineering Reference
In-Depth Information
Figure 9.4
Heat map (log
ratios of SNP copy number) for GIST samples
analyzed by Affymetrix Genome-Wide Human SNP Array 6.0.
The color scale ranges from bright red (copy number loss) to
white to bright blue (copy number gain). Case numbers and
mutation status are indicated at the top. Chromosome numbers
are shown to the left of the figure, p and q arms are separated
by hash marks. Lane #11 represents a
2
mutation carrier
and #15 represents a pediatric GIST samples (adapted from
[19] and Belinsky and Godwin, unpublished data).
BRAF
9.3.6
Risk Assessment
Accurate risk stratification of GISTs has become increasingly
important as effective adjuvant therapy emerges. The National
