Biomedical Engineering Reference
In-Depth Information
Table 1.1
Therapeutic biomarker categories based on their applications
Risk
identification
Biomarker / drug
Benefit Resistance Toxicity
c-Kit expression or mutations in GIST / Imatinib
X
BCR-ABL fusion gene (Ph+) in leukemia / Anti-BCR-ABL agents
X
BCR-ABL/T315I mutation / anti-BCR-ABL agents
X
BRAF
V600E
mutation in melanoma / BRAF kinase inhibitors
X
BRCA dysfunction in solid tumors / PARP inhibitors
X
DPD deficiency / 5-fluorouracil
X
EGFR gene mutations in NSCLC / EGFR tyrosine kinase inhibitors
X
EGFR expression in colorectal cancer / anti-EGFR antibodies
X
EML4-ALK fusion gene in lung cancer / ALK inhibitors
X
ER and/or PR in breast cancer / endocrine therapy
X
