Biomedical Engineering Reference
In-Depth Information
Drug
Class/
mechanisms of action
Indications
Dose
Major side effects
Toremifene
(Fareston
®
)
SERM:
-Nonsteroidal triphenylethylene
derivative
-Binds to ER and may exert
estrogenic, antiestrogenic, or
both activities, depending upon
the duration of treatment, animal
species, gender, target organ, or
endpoint selected
-The antitumor efect is believed
to be mainly due to its ability
to compete with estrogen for
binding sites in the cancer,
blocking the growth-stimulating
efects of estrogen in the tumor
Advanced/Metastatic:
Postmenopausal women with
estrogen-receptor positive or
unknown metastatic breast cancer
60 mg once
daily
-Hot flashes
-Vaginal discharge
-Thromboembolic
event
-Endometrial cancer
(
Continued
)
