Biology Reference
In-Depth Information
reported to interact physically with Broad (
Faucheux et al., 2003
). Interest-
ingly, genome-wide protein-protein interaction data suggest that Batman
can interact with Ttk (
Murali et al., 2011; Pacifico et al., 2006; Yu &
Finley, 2009; Yu, Pacifico, Liu, & Finley, 2008
). Taken together, these in-
teresting anecdotal data raise the possibility that Ttk could form multimers
not just with itself but also with other proteins such as Broad and Batman
(
Bonchuk, Denisov, Georgiev, & Maksimenko, 2011
).
11.8. CRC/ATF4 (cryptocephal)
The
cryptocephal
gene encodes the
Drosophila
homolog of vertebrate ATF4,
which belongs to the CREB/ATF family of basic leucine zipper (bZIP) pro-
teins (
Hewes et al., 2000; Persengiev & Green, 2003
). Mutations in
crc
result
in a range of developmental abnormalities, including molting defects, the
failure of the gas bubble to translocate during pupal development, the ab-
sence of head eversion, and defects in imaginal disks elongation. Together,
these data show that
crc
is crucial for controlling molting and metamorphosis
in
Drosophila
(
Hewes et al., 2000
). Further,
crc
is required for the expression
of the ecdysis triggering hormone (
Gauthier & Hewes, 2006
).
crc
is strongly
expressed in the larval ring gland, the CNS, and the imaginal disks in third
instar larvae at the wandering stage, raising the possibility that
crc
might exert
its control over metamorphic processes through controlling ecdysone bio-
synthesis as well as acting downstream of the hormone in target tissues.
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