Biology Reference
In-Depth Information
Table 2.1 Transcription factors with roles in the prothoracic gland
Transcription
factor
Domain
information
Mutant
phenotype
a
Signaling
pathway
Putative
target
PG expression
b
Reference
EcR (
EcR
)
Znf-C4, LBD
(NR family)
Embyronic
lethal
Immunostaining
(EcR-A)
Negative
feedback?
?
Talbot et al. (1993)
USP (
ultraspiracle
) Znf-C4, LBD
(NR family)
L1 lethal
WB on
Manduca
PG
Negative
feedback?
?
Song & Gilbert (1998)
E75A (
Eip75B
)
Znf-C4, LBD
(NR family)
Larval/pupal
lethal
Immunostaining NO
signaling
ftz-f1
Caceres et al. (2011)
E75B (
Eip75B
)
Znf-C4, LBD
(NR family)
Viable
Immunostaining NO
signaling
ftz-f1
Caceres et al. (2011)
DHR3 (
DHR3
)
Znf-C4, LBD
(NR family)
Embryonic
lethal
Immunostaining NO
signaling
ftz-f1
Caceres et al. (2011)
DHR4 (
DHR4
)
Znf-C4, LBD
(NR family)
Prepupal
lethal
Immunostaining
PTTH
signaling
Cyp6t3
King-Jones et al. (2005)
FTZ-F1 (
ftz-f1
) Znf-C4, LBD
(NR family)
Embryonic
lethal
ISH,
immunostaining
NO
signaling
dib
and
phm
Parvy et al. (2005)
,
Caceres et al. (2011)
b
WOC (
without
children
)
Znf-C4
Larval lethal
ISH
?
7,8-
Dehydrogenase
activity
Wismar et al. (2000)
MLD (
molting
defective
)
Znf-C2H2
L1 lethal
Immunostaining
?
spok
Neubueser, Warren,
Gilbert, and Cohen (2005)
DRE4 (
dre4
)
FACT/DUF1747
domain
Larval and
pupal lethal
Genetic evidence ?
?
Sliter & Gilbert (1992)
