Biology Reference
In-Depth Information
Transcription
307 genes
Signal transduction
367 genes
Brain
Limb
Tail
Brain
Limb
Tail
Mitochondria
184 genes
Cell cycle
191 genes
Brain
Limb
Tail
Brain
Limb
Tail
Figure 12.3 Comparison of altered gene expression among brain, limb, and tail. From
Das et al. (2006)
, significantly regulated genes in brain, limb, or tail after 48 h of 100 nM
T3 were grouped by gene ontology categories. Here, we chose to display genes from
transcription, signal transduction, mitochondria, and cell cycle. Genes up- or down-
regulated or no change were assigned green, red, or black, respectively, then sorted
by color starting with brain, then limb, and then tail. Among tissues, the gene regulation
patterns for each GO category indicate that brain and limb are more similar to each
other than to tail, matching their response to TH after 2 days, that is, proliferation versus
apoptosis. Among GO categories, gene regulation patterns were similar between tran-
scription and signal transduction and between mitochondria and cell cycle. For exam-
ple, gene expression patterns among tissues are much more similar to each other in the
transcription and signal transduction categories compared to the mitochondria and cell
cycle categories.
