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been shown to contain TH response elements in the mammalian intestine,
suggesting the direct action of TH on canonical Wnt/
b
-catenin pathway
(
Plateroti et al., 2006
). It is thus interesting from the standpoints of both evo-
lution and stem cell biology to know how far molecular mechanisms regu-
lating the adult stem cells are depend on TH and are conserved among
amphibian intestinal remodeling, mammalian intestinal maturation, and ho-
meostasis of the both intestines during adulthood. Their comparative studies
should help us to fully elucidate the molecular nature of the intestinal stem
cell niche, which can serve as a base for regenerative and cancer therapies.
ACKNOWLEDGMENTS
We thank Dr. Yun-Bo Shi for our longtime research collaboration and Emeritus Professor
Takeo Mizuno for his continuous encouragement. This work was supported in part by the
JSPS Grants-in-Aid for Scientific Research (C) (Grant number 24570078 to A. I.-O.).
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