Biomedical Engineering Reference
In-Depth Information
*Monkeypox virus
*Vaccinia virus
*Variola major virus
*Variola minor virus
Parapoxvirus
*Orf
*Milker's node virus
Molluscipoxvirus
*Molluscum contagiosum virus
Yatapoxvirus
*Tanapoxvirus
*Yaba monkey tumor virus
Mimiviridae
Mimivirus
*Acanthamoeba polyphaga mimivirus (pneumonia)
Group II, ssDNA (Chapter 40)
Group III, dsRNA (Chapter 41)
Group IV (
1
)ssRNA (Chapter 42)
Group V (
)ssRNA (Chapter 43)
Group VI, ssRNA-RT (Chapter 44)
Group VII, dsDNA-RT (Chapter 45)
Prions (Chapter 46)
2
The Group I viruses all have a double-stranded DNA genome. Aside from
this property, the viruses vary greatly. Some species have envelopes; others
do not. Some species have circular genomes; others have linear genomes.
The size of the viral genome can vary as much as 50-fold among different
species of the group. The host range covers the range of living organisms.
Eubacteria, Archaeans, single-celled eurkaryotic organisms, and various
animals are infected by one or another Group I virus. The group has been sub-
classed based on shared morphologic properties, six of these subclasses contain
human pathogens: Adenoviridae, Herpesviridae, Poxviridae, Papillomaviridae,
Polyomaviridae, and Mimiviridae.
Most of the DNA-transforming viruses (i.e. DNA viruses that cause cancer)
belong to Group I: Polyomaviruses, Adenoviruses, Papillomaviruses, and
Herpesviruses (including Epstein
Barr virus). The one exception is Hepatitis B
virus, which belongs to Group VII (Chapter 45). Unlike the retroviruses (Group
VI, Chapter 44), which contain genes that are homologous with cancer-causing
oncogenes, the DNA-transforming viruses do not contain oncogenes. The
Group I DNA transforming viruses seem to cause cancer through a mechanism
related to their ability to induce replication in their host cells.
Group I, dsDNA
Herpesvirales
Herpesviridae
