The Role of MicroRNAs in Muscle Development - Current Topics in Developmental Biology - page 68

Table 3.1 Muscle development phenotypes of miRNA mutant animals

Gene Animal Phenotype References

miR-1 C. elegans No obvious developmental phenotype Simon et al . (2008)

miR-1 D. melanogaster Muscle growth Sokol and Ambros (2005)

Muscle patterning Kwon et al . (2005)

let-7-C D. melanogaster NMJ and muscle growth Caygill and Johnston (2008) ; Sokol et al . (2008)

miR-1-2 M. musculus 50% lethality, cardiac defects Zhao et al . (2007)

miR-17-92 M. musculus 100% postnatal death, cardiac defects Ventura et al . (2008) ; Wang et al . (2010)

miR-133a-1 M. musculus No obvious developmental phenotype Liu et al . (2008)

miR-133a-2 M. musculus No obvious developmental phenotype Liu et al . (2008)

miR-133a-1/-2 M. musculus

Liu et al . (2008)

50% lethality, cardiac defects

miR-143 M. musculus No obvious developmental phenotype Xin et al . (2009)

miR-145 M. musculus Thinner smooth muscle layer in arteries Xin et al . (2009)

miR-143/145 M. musculus Similar to miR-145 phenotype Elia et al . (2009) ; Xin et al . (2009)

miR-206 M. musculus No obvious developmental phenotype Williams et al . (2009)

miR-208a M. musculus No obvious developmental phenotype van Rooij et al . (2007) ; Callis et al . (2009)

miR-208b M. musculus No obvious developmental phenotype van Rooij et al . (2009)

miR-499 M. musculus No obvious developmental phenotype van Rooij et al . (2009)

miR-208b/-499 M. musculus Loss of slow myofibers in skeletal muscle van Rooij et al . (2009)