Biology Reference
In-Depth Information
Drosophila melanogaster
lab
pb
zen
bcd
Dfd
Scr
ftz
Antp
Ubx
zen2
abdA
AbdB
miR-993
Protostomia
miR-iab-4/8
Arthropoda
miR-993 miR-10
miR-iab-4/8
Tribolium castaneum
lab
pb
zen
Dfd
Scr
ftz
Antp
Ubx
zen2
abdA
AbdB
miR-993 miR-10
miR-iab-4/8
miR-10
Bilateria
Daphnia pulex
lab
pb
3
Dfd
Scr
ftz
Antp
Ubx
abdA
AbdB
miR-10
Strongylocentrotus purpuratus
5
6
7
8
3
2
1
9/10
11/13a
11/13b
11/13c
miR-10-1 miR-10-2
miR-10-3
Branchiostoma floridae
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
miR-196b
A
1
2
3
4
5
6
7
9
10
11
13
miR-10a
miR-196a-1
B
1
2
3
4
5
6
7
8
9
10
13
Callorhinchus milii
miR-10c
miR-196a-2
C
1
3
8
9
10
11
12
13
miR-10b
D
3
4
5
8
10
13
14
miR-196b
A
1
2
3
4
5
6
7
9
10
11
13
miR-10a
miR-196a-1
B
1
2
3
4
5
6
7
8
9
13
Xenopus tropicalis
miR-10c
miR-196a-2
C
3
4
5
6
8
9
10
11
12
13
miR-10b
D
1
3
4
8
9
10
11
12
13
miR-196
miR-196b
A
1
2
3
4
5
6
7
9
10
11
13
miR-10a
miR-196a-1
B
13
1
2
3
4
5
6
7
8
9
Mus musculus
miR-615
miR-196a-2
C
4
5
6
8
9
10
11
12
13
miR-615
Eutheria
miR-10b
D
1
3
4
8
9
10
11
12
13
miR-196a-2
Aa
1
3
4
5
9
11
13
miR-10c
miR-196b
Ba
1
2
3
4
5
6
7
8
9
10
13
miR-10b-2
miR-196a-1
Ca
1
3
4
5
6
8
9
10
11
12
13
miR-10b-1
Da
3
4
9
10
11
12
13
Danio rerio
miR-196d
Ab
2
9
10
11
13
miR-10a
Bb
1
5
6
8
miR-196c
Cb
6
11
12
13
miR-10d
Db
Figure 2.1 Phylogenetic distribution of Hox-embedded miRNA families. The five
known families of miRNAs that have become positioned within bilaterian Hox clusters
are diagrammed for several organisms. Each cluster is shown as a line, with blue arrows
representing protein encoding genes and smaller arrows representing the miRNAs
indicated ( miR-10 : light blue; miR-993 : dark blue; miR-iab-4/8 : yellow; miR-196 :
green; miR-615 : red). The direction of transcription for each gene is indicated. Lineages
within which each miRNA family became incorporated into Hox clusters are indicated
on the cladogram. Homeobox genes that remain clustered but have lost Hox function
(in insects) and are shown in gray. Please note that neither branch lengths nor gene or
intergenic sequence lengths are drawn to scale, and this diagram does not reflect
substantial variation in cluster sizes, intergenic DNA length and composition, sizes,
structures, or splice isoforms of individual Hox transcripts, which are beyond the scope
of this review.
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