Biology Reference
In-Depth Information
CHAPTER TWO
Evolution, Expression, and
Developmental Function of
Hox-Embedded miRNAs
Jennifer H. Mansfield
*
and
Edwina McGlinn
†
Contents
1. Introduction
32
36
2. Genomic Organization and Evolution
36
2.1. Hox clusters
2.2. Hox-embedded miRNAs
37
3. Predicted Targets of Hox-Embedded miRNAs: A Role in Posterior
Prevalence, and More?
39
42
4.
miR-10
4.1. Transcript structure, processing, and regulatory mechanisms
42
43
4.2. Developmental expression, target predictions, and function
5.
miR-iab-4/miR-iab-8
45
5.1. Transcript structure, processing, and upstream regulatory
mechanisms
45
46
5.2. Integrating developmental expression with target predictions
47
5.3. Function
6.
miR-196
48
6.1. Transcript structure, processing, and upstream regulatory
mechanisms
48
49
6.2. Integrating developmental expression with target predictions
6.3. Function
50
51
7. Summary and Conclusions
7.1. Note added in proof
53
Acknowledgments
53
References
54
* Department of Biology, Barnard College, New York, USA
{
EMBL Australia, Australian Regenerative Medicine Institute, Monash University, Clayton, Australia
