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Table 6.2
MicroRNAs that regulate hematopoietic development
Transcription
factor/nuclear
protein
Knockout/loss-of-function
phenotype
Overexpression
phenotype
Receptor
signaling
miRNA
Critical targets
Apoptosis
miR-150
Defective B cell development
Block in B cell
development
Myb
miR-34a
Enhanced B cell output
Block in B cell
development
Foxp1
miR-223
Increased granulocyte
compartment
nd
Mef2c
miR-196b
nd
Decreased HSC
repopulating
potential
Hox genes
miR-29a
nd
MPD progressing
to AML
Dnmt3a
miR-326
Inhibited Th17 development
Increased Th17
development
Ets1
miR-155
Impaired Ig class switching,
decreased inflammatory
T cells, and dysfunctional
GM cells
MPD or B cell
leukemia
PU.1, Ship1,
cMaf, Socs1,
Aicda
miR-146a
Eventual MPD progressing
to cancer
Perturbed
hematopoiesis
Irak1, Traf6, Stat1
miR-21
nd
B cell lymphoma Pdcd4
miR-451
Impaired RBC development
nd
14-3-3zeta
miR-181a
Defective TCR signaling
Increased B cell
development
Dusp5, Dusp6,
Shp2 and Ptpn22
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