Biology Reference
In-Depth Information
Table 6.1
Genes with happloinsufficient hematopoietic phenotypes
Conserved
miRNA
sites (targetscan)
Transcription
factor/nuclear
protein
Receptor
signaling
Apoptosis/
cell cycle
Gene
Haploinsufficient phenotypes
Myb
Altered lymphocyte development
13
Tp53
UV-induced B cell lymphoma
3
PU.1
Granulocyte versus monocyte skewing
1
Runx1
Decreased HSCs
19
Aicda
Decreased Ig diversification and translocations
2
Arf
Rescued B cell development
2
Egr1
Myeloid disorders
3
Mcl1
Resistant to cMyc induced AML
10
Prpf19
Defective HSC function
4
EBF1
Defective B cell development
17
Bcl11b
Decreased T cell development
33
Npm1
Increased blood cancers
1
Shp2
Decreased HSC function
7
Apc
Ineffective hematopoiesis
12
Socs1
Enhanced sensitivity to endotoxemia
4
Pten
Myelodysplasia
22
Bim
Increased B cell lymphoma
25
Cdkn1b
Increased T cell leukemia
5
