Biology Reference
In-Depth Information
CHAPTER SIX
MicroRNAs and Hematopoietic
Cell Development
Ryan M. O'Connell
*
and
David Baltimore
†
Contents
1. Introduction
146
2. The Emerging Importance of MicroRNAs During Hematopoietic
Development
147
2.1. MicroRNAs and the stabilization of complex phenotypes
147
2.2. MicroRNAs fine-tune gene expression levels in the
hematopoietic system
148
149
2.3. Combinatorial gene regulation by miRNAs
2.4. MicroRNAs and aging
151
152
3. Controlling MicroRNA-Mediated Repression of mRNA Targets
3.1. MicroRNA biogenesis and function
152
153
3.2. MicroRNA turnover
3.3. Regulating miRNA interactions with mRNA 3
0
UTRs
154
155
4. MicroRNAs Regulate Different Stages of Hematopoiesis
155
4.1. Hematopoietic stem cells
157
4.2. Lymphoid versus myeloid
159
4.3. Reactivation of development
5. MicroRNAs During Hematopoietic Stress and Disease
159
160
5.1. Inflammatory hematopoiesis
5.2. Cancer
161
162
5.3. Other hematopoietic disorders
6. Concluding Remarks
163
Acknowledgments
166
References
167
Abstract
Hematopoiesis is a dynamic and highly complex developmental process that
gives rise to a multitude of the cell types that circulate in the blood of multicellu-
lar organisms. These cells provide tissues with oxygen, guard against infection,
* Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City,
Utah, USA
{
Division of Biology, California Institute of Technology, Pasadena, California, USA
