Biomedical Engineering Reference
In-Depth Information
FIGURE 5.2: The initial condition (i.e., at t = 0) of the ARO cell mass for
all sets of simulations. The cell monolayer is scraped at the right border by a
wound of 0.35 mm (175 px). The dimensions of the cells, as well as all the
other model parameters, are given in Appendix C. On the right panel is the
initial frame of the experimental assay [349].
constant rates given by
pr
,
kr
, and
cr
, respectively. Given the value
of
cr
provided in the case of a moving keratocyte in [254], in the absence
of other specific published estimates, we set
pr
=
kr
=
cr
.
5.3 Simulations
The simulation domain is a bidimensional lattice of 350 500 sites. The
characteristic length of each site is 2 m: therefore represents a section of a
24-well of size 0.7 mm 1 mm. One MCS is set to correspond to 2 s. The initial
conditions of all simulations consist of a mass of ARO cells, whose dimensions
are given in Tables C.1 and C.5, scraped at one side border by a wound of
0.35 mm (175 px); see Figure 5.2. The dimension of the scratch is lower than
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