Biomedical Engineering Reference
In-Depth Information
TABLE C.5: (Continued.)
Parameter
Description
Value
Reference
h
Michaelis{Menten constant for T
1/2
[352]
T
;N
Generalized motility of the nucleus
0.25
[352]
10
13
[m
2
s
1
]
D
h
HGF diffusion constant
[349]
10
4
[s
1
]
h
HGF on-rate degradation constant
[349]
10
4
[s
1
]
h
HGF on-rate addition constant
[349]
1 [s
1
]
z
Coecient of the amount of HGF in-
ternalized
[352]
nr
Total number of Met receptors
311.200
[352]
5 [m
2
s
1
]
D
p
PI3K diffusion constant
[243]
1 [s
1
]
p
PI3K on-rate degradation constant
[243]
10 [Ms
1
]
p
Maximal
rate
of
Met-dependent
[60]
PI3K activation
p;0
Constant for Met-dependent PI3K
activation
2 [M]
[60]
D
k
MAPK diffusion constant
2 [m
2
s
1
]
[210, 255]
1 [s
1
]
k
MAPK
on-rate
degradation
con-
[210, 255]
stant
10 [Ms
1
]
k
Maximal
rate
of
Met-dependent
[60]
MAPK activation
k;0
Constant for Met-dependent MAPK
activation
2 [M]
[60]
D
r
Rac diffusion constant
10
5
[nm
2
s
1
]
[254]
1 [s
1
]
r
Rac on-rate degradation constant
[254]
4.5 [s
1
]
pr
Rate of PI3K-dependent Rac activa-
tion
[352]
4.5 [s
1
]
kr
Rate of MAPK-dependent Rac acti-
vation
[352]
4.5 [s
1
]
cr
Rate of Cdc42-dependent Rac acti-
vation
[254]
10
5
[nm
2
s
1
]
D
c
Cdc42 diffusion constant
[254]
1 [s
1
]
c
Cdc42 on-rate degradation constant
[254]
2.5 [s
1
]
pc
Rate of PI3K-dependent Cdc42 ac-
tivation
[352]
kc
Rate
of
MAPK-dependent
Cdc42
3 [s
1
]
[352]
activation
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