Biomedical Engineering Reference
In-Depth Information
TABLE C.4: OvCa Multicellular Spheroid Invasion. () indicates parameters
that vary in the different sets of simulations.
Parameter
Description
Value
Reference
A
surface
C
Target surface of cancer cells
56 [px]
[234]
surface
C
5 [px
2
]
Compressibility of cancer cells
[162]
J
C;C
Adhesion between cancer cells
0.1*
[162]
J
C;M
Adhesion between cancer cells and
mesothelial cells
9
[234]
m
MMPs secretion rate
0.3*
[MCS
1
]
[162]
g
Gravitational potential
9.8
TABLE C.5: Wound Healing Assay of ARO Cells in Response to HGF.()
indicates parameters that vary in the different sets of simulations.
Parameter
Description
Value
Reference
A
surface
;N
50 [m
2
]
Surface of cell nucleus
[101, 349]
A
perimeter
;N
Perimeter of cell nucleus
43 [m]
[101, 349]
A
surface
;C
Surface of cell cytosol
150 [m
2
]
[101, 349]
A
perimeter
;C
Perimeter of cell cytosol
90 [m]
[101, 349]
A
surface
;M
60 [m
2
]
Surface of cell plasmamembrane
[101, 349]
A
perimeter
;M
Perimeter of cell plasmamembrane
60 [m]
[101, 349]
surface
;N;C;M
Cell compressibility
20
[352]
perimeter
;N;C;M
Cell stiffness
20
[352]
J
int
C;N
Generalized adhesion between nu-
cleus and cytoplasm
-20
[352]
J
int
C;M
Generalized adhesion between cyto-
plasm and plasmamembrane
-20
[352]
J
0
Basal adhesive strength
4.5
[101, 349]
Coecient for J
ext
E;E
1/2 [M
2
]
k
[352]
T
0
Basal cell motility
0.4
[101]
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