Biomedical Engineering Reference
In-Depth Information
TABLE C.3: OvCa Single Cell Transmigration. () indicates parameters that
vary in the different sets of simulations.
Parameter
Description
Value
Reference
T
C
Motility of cancer cells
20
[162]
T
M
Motility of mesothelial cells
10
[162]
T
E
Motility of ECM fibers
0
[162]
A
surface
C
Target surface of cancer cells
175 [px]
[162]
A
surface
M
Target surface of mesothelial cells
243 [px]
[162]
A
perimeter
C
Target perimeter of cancer cells
70 [px]
[162]
A
perimeter
M
Target perimeter of mesothelial cells
72 [px]
[162]
surface
C
3 [px
2
]
Compressibility of cancer cells
[162]
surface
M
Compressibility of mesothelial cells
10 [px
2
]
[162]
perimeter
C
5 [px
1
]
Stiffness of cancer cells
[162]
perimeter
M
10 [px
1
]
Stiffness of mesothelial cells
[162]
J
C;F
Adhesion between cancer cells and
extracellular fluid
15
[162]
J
M;F
Adhesion between mesothelial cells
and extracellular fluid
5
[162]
J
E;F
Adhesion between matrix fibers and
extracellular fluid
6
[162]
J
C;E
Adhesion between cancer cells and
matrix fibers
1
[162]
J
C;M
Adhesion between cancer cells and
mesothelial cells
1*
[162]
J
M;E
Adhesion between mesothelial cells
and matrix fibers
1
[162]
J
M;M
Adhesion between mesothelial cells
0.3*
[162]
J
C;S
Adhesion between cancer cells and
Petri dish
0.5
[162]
chem
C
30 [M
1
]
Chemotactic strength of cancer cells
[162]
[px
2
D
m
MMPs diffusion rate
0.02
[408]
MCS
1
]
m
MMPs decay rate
0.01
[MCS
1
]
[408]
m
MMPs secretion rate
0.25*
[MCS
1
]
[408]
[px
2
D
c
Chemoattractant diffusion rate
0.1
[162]
MCS
1
]
c
Chemoattractant decay rate
0.001
[MCS
1
]
[162]
0.2 [MCS
1
]
c
Chemoattractant secretion rate
[162]
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