Biomedical Engineering Reference
In-Depth Information
FIGURE 10.6: Cell migration dynamics inside the different channels in the
case of cells able to remodel both their cytoplasm and their nucleus. Typical
profile of a sliding-like migration pattern, where the cell front, nucleus and
rear are moving in a synchronous way, is observed for large and intermediate
channel structures (top and middle panels). Typical profile of a push-and-
pull-like migration behavior, where the cell front smoothly moves while rear
moves in an oscillating manner (i.e., depending of the time taken by nucleus
to deform and displace) is found in the case of the smallest channel (bottom
panel). The relative position of the different cell parts is plotted as the mean
s.d. over 50 \eective" (see denition in Figure 10.5) realizations.
Indeed, we consider the case of completely deformable individuals (i.e.,
with elastic subcompartments). As reproduced in Figure 10.6 (top and middle
panels), for large and medium channels, we observe a smooth sliding motion,
characterized by an equidistant movement of the cell internal regions, that
maintains the overall cell length. In particular, in the intermediate structure,
the cell front is significantly distant from the central and the back parts of
Search WWH ::
Custom Search