Biomedical Engineering Reference
In-Depth Information
FIGURE 10.1: Sections of the simulation domain . The lattice reproduces
a micro-fabricated device with channels of various widths and a planar sur-
face just outside their entrance. In particular, the top channel is larger than
the overall cell diameter, while the bottom channel is smaller than nuclear di-
mensions. Initially, the cells are seeded on the flat substrate near the channel
walls.
Cells that only penetrate a channel with a part of their cytoplasm but
not with the nucleus are called (partially) penetrating.
Cells that completely enter in a channel structure but are not able to
migrate to the other side within the observation period are called inva-
sive.
Cells that reach the opposite border of a channel are finally called per-
meative.
In the first set of simulations, we force cancer cells to maintain their hemi-
spherical shape by setting high
surface
;C
=
surface
;N
= 15. This is the model
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