Cell Migration in Extracellular Matrices - Cellular Potts Models: Multiscale Extensions and Biological Applications - page 179

FIGURE 9.7: Biphasic relationship of cell motility and cell-fiber adhesion
strength, given by the model parameter J ext

E;F , for both 2D or 3D matrices. All
other parameters remain unchanged, such as in the standard case of Figure
9.1. The values of cell MSD, average velocity, and persistence time are given as
means s.d. over 50 randomly selected cells. The maximal migratory capacity
is seen at intermediate values of cell-fiber adhesiveness.

cell velocity, whereas the persistent component of cell motion remains almost
unaltered and refers to random movement (recall Figure 9.1). In particular,
persistence levels smaller than 1 at the lowest and highest J ext

E;F levels corre-
spond with a running on the spot phenotype observed in experimental assays
for cells embedded in matrix [411].
Bimodal relations between cell migratory phenotype and cell adhesiveness
with planar substrates has been captured in [106], where cell{matrix attach-
ment strengths have been quantified by the critical shear stress measured using
a modified radial-flow detachment assay, and in [167], where maximal locomo-
tion of murine skeletal muscle myoblast over polystyrene surfaces coated with
laminin (Ln) and fibronectin (Fn) has been demonstrated to occur at approx-
imately one-third to one-half of the maximum adhesive strength. In [118], an