Biomedical Engineering Reference
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FIGURE 9.4: A bimodal relationship is observed also between cell migratory
capacities and density of the fibrous component of the matrices, in both 2D
(left panels) and 3D (right panels). In both cases, an increasing number of
collagen-like threads is isotropically distributed as in the simulations referring
to Figure 9.1. In particular, in three dimensions, increments in fiber number
lead to decrements in pore sizes. Wind-rose graphs show 10 randomly chosen
cell tracks over 12 h in the case of different densities of matrix fibers.
reasons and mechanisms are different. In the planar substrate, the overabun-
dance of matrix threads causes cells to lose their preference toward collagen
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