Biomedical Engineering Reference
In-Depth Information
FIGURE 8.7: Invasiveness of the tumor mass in response to alterations in
cell membrane elasticity,
perimeter
;C
(i.e., all the other model parameters are
the same as in the simulation in Figure 8.7). Increments in cell ability to
remodel cause dramatic increment in malignant aggressiveness, as the cells
can eciently traverse the host tissue. On the contrary, if cells are forced
to maintain their shape, they behave as rigid bodies and do not venture far
from the front of the main mass. Examples of final configurations for (A)
perimeter
;C
= 1 and (B)
perimeter
;C
= 8. (C) Final depth of invasion df
f
vs.
perimeter
;C
. The error bars show standard deviation over 10 realizations.
pattern remains almost homogeneous and significantly inhibits the haptotac-
tic component of the migration of cancer cells (that is fundamental for tumor
Search WWH ::
Custom Search