Biomedical Engineering Reference
In-Depth Information
FIGURE 8.5: Invasiveness of the tumor mass in response to alterations of
cell{cell adhesive strength, J
ext
T;T
(i.e., all the other model parameters are the
same as in the simulation in Figure 8.4). Decrements in cell{cell adhesion lead
to increments in the malignancy of the lesion. On the contrary, by enforcing
cell{cell adhesion, the mass remains compact and smooth with a low invasive
potential. Examples of final configurations for (A) J
ext
T;T
= 1 and (B) J
ext
T;T
= 8.
In this last case, it is possible to see islands of free matrix formed in the main
body of the mass, as repulsion occurs also among internal individuals. (C)
Final depth of invasion df
f
vs. J
ext
T;T
. The error bars show standard deviation
over 10 realizations.
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