Biomedical Engineering Reference
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FIGURE 8.4: (See color insert.) Invasion of the tumor mass and relative
modification of the microenvironment with the standard parameter setting,
given in the Appendix. (A) Regions in which the tumor mass is divided form
its front, i.e., external (dark border) and internal (light border). (B) Con-
guration at t = 15000 MCS 4 days. (C) ECM protein distribution and
(D) growth factor concentration in the host tissue at the end of malignant
invasion.
\external" cells (i.e., those placed near the front of the mass, see dark bor-
dered region in Figure 8.4(A)), which loosen contacts, dissociate, move from
their original site and start wandering in the close proximity, displaying an
evident ability to spread in the surrounding tissue. The increased metabolism
of these individuals is due to the availability of growth factors which, together
with the interactions with the local microenvironment (both the haptotactic
movement and adhesive preference for ECM components) induces a sort of
mesenchymal transition able to overcome the physiological regulation of the
mechanism of contact-inhibition of cell locomotion (firstly proposed by Aber-
 
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