Effect of Calcium{Related Pathways on Single Cell Motility - Cellular Potts Models: Multiscale Extensions and Biological Applications - page 98

FIGURE 6.8: (See color insert.) Partial inhibition of overall VEGF-induced
calcium influx F TOT = F AA + F NO . (A) Three-dimensional view of cell po-
sition at t = 6 h for each F TOT -decrement. Red dot represents the VEGF
source. Contour plots showing the final intracellular calcium profile in (B) z
= 1 m plane and (C) y = 50 m plane. Calcium concentration has been
pseudocolor-scaled so that the maximum value is red. (D) Evolution in time
of cell directional velocity v x . The complete inhibition of calcium responses
(F TOT = 0) dramatically stops cell directional motility (x CM (t = 6 h) = 20
m and v x 3:3 m/h). (E) Maximal Ca 2+ concentration at t = 6 h. The
error bars show standard deviation over 10 simulations.