Biomedical Engineering Reference
In-Depth Information
FIGURE 5.5: (See color insert.) Comparison of the dynamics of the three
subpopulations. (A) Polar plots of the net displacements of 20 representative
cells randomly selected within each subpopulation. (B) Mean linearity and
(C) time evolution of the modulus of velocity for each subpopulation.
been described in detail for epithelial cell lines [420] and fibroblast cultures
[393] and was first proposed by Abercrombie to describe the influence on cell
crawling of the contact interactions between individuals [1].
It is finally useful to emphasize that the proposed model is highly flexible,
as, in principle, it can be applied to any cell population stimulated by any
motility agent only by changing either the parameters describing the cell basal
properties or the microscopic models of chemical dynamics. For instance, as
evident biomedical relevant examples, applying our approach to an epithelial
cell culture allows one to test the physiological conditions in which the recovery
of skin lesions is more ecient. On the contrary, using it for a malignant cell
line, allows one to test potential therapies able to interfere with the ability of
tumors to expand and invade.
 
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