Circadian Clocks, Food Intake, and Metabolism - Progress in Molecular Biology and Translational Science - page 126

5. CONCLUSION

In spite of the huge literature demonstrating the tight connections
between circadian clocks and metabolism in animals, much work remains
to be done to confirm in humans the conclusions drawn in nocturnal
rodents. Nevertheless, epidemiological studies consistently report an
increased prevalence of metabolic risk factors in shift workers and other
desynchronizing conditions. Therefore, it is relevant from a clinical point
of view to improve basic knowledge and develop models of shift work
and other circadian disturbances in day-active animals. In view of the more
and more recognized importance of (circadian) timing in pathophysiology,
pharmacological and dietary interventions for limiting metabolic risks could
take into account circadian rhythmicity to maintain and/or restore a tem-
poral organization appropriately synchronized to local time.

ACKNOWLEDGMENTS
I would like to thank Pr. Martha Gillette for the invitation to write this chapter, and Pr. Paul
P´vet and Pr. Andr´ Malan for guidance and support. I also thank for their help and discussion
all my colleagues of the “Regulation of circadian clocks” team at the Institute of Cellular and
Integrative Neurosciences, CNRS, and University of Strasbourg.

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