Single-Chain Polymer Nanoparticles for Application in Nanomedicine - Harnessing Biomaterials in Nanomedicine: Preparation, Toxicity, and Applications - page 32

Scheme 2.5 Formation and intramolecular collapse of the PEG-b-PSt/BCB
block copolymer, 15, to give a hybrid linear-nanoparticle copolymer, 16.
Reproduced from ref. [29] with permission.
In a more recent paper, Liu and co-workers synthesise
diblock copolymers of poly( tert -butyl acrylate)- block -poly(2-
cinnamoyloxyethyl methacrylate) and poly( tert -butyl acrylate)-
block -poly[(2-cinnamoyloxyethyl methacrylate)- ran -(2-
hydrocinnamoyloxyethyl methacrylate)] [53]. The partial collapse
of the cinnamoyl-containing blocks was carried out using the same
photo-cross-linking strategy previously described [50]. Thus, the
tadpoles were prepared by adding a diblock copolymer solution
gradually into a solvent, under constant UV irradiation and stirring.
One of the advantages of this method is that it is carried out at room-
temperature, unlike Hawker's BCB-based systems which require
very high temperatures.
Finally, an A-B-C type triblock copolymer can also be designed
to undergo partial collapse of one of the blocks. In a recent example