Biomedical Engineering Reference
In-Depth Information
Eachparthasauniqueand
importantcontribution
Extraliposome
medium
Lipid bilayer hydrophobic
part [rigid LO]
Intraliposome
precipitateddrug
Hydrated and charge
hindered headgroups
by PEG
Head group attached
Flexible highly
hydrated polymer
Intraliposome
aqueous phase
Intraliposome
aqueousphase
A cartoon of Doxil
®
= pegylated nano (<100 nm) unilamellar
liposome. It is based on cryo-TEM, SAXS, WAXS, DLS, compressibility, and
doxorubicin absorbance and fluorescence (Lasic et al., 1992, 1995; Haran et
al., 1993; Tirosh et al., 1998).
Figure 12.7
CAELYX
™
(
n
=109)
Topotecan(
n
=111)
100
CAELYX
™
108 weeks
80
P
=.008
%
60
P
a
t
I
e
n
t
s
40
20
Topotecan
71.1weeks
weeks
weeks
0
0
20
0
40
60 80 100 120 140
TM
Figure 12.9
(= Doxil) is superior to topotecan in ovarian cancer
(from Gordon et al., 2001).
Caelyx
