Biomedical Engineering Reference
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Figure 11.1
Immune recognition of nanoparticles. Map of diferent
nanoparticles on a diameter vs. Mw chart; blue shaded area is the region of
immune recognition. Liposomes and carbon nanotubes, with their length,
fall into the “sight” of the immune system, while smaller nanoparticles
(fullerenes, dendrimers, micelles and complex polymeric particles (e.g.,
nanolatex) are, in theory, below the size and Mw thresholds of immune
recognition. The green “Lipinsky box” shows the position of traditional
small-molecular weight drugs [62].
Figure 11.4
Mechanism of complement activation-related pseudoallergy
(CARPA) caused by liposomes and micelles. Crel-Cremophor EL, PS80-
polysorbate 80, R-receptor.
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