Biomedical Engineering Reference
In-Depth Information
Special Acknowledgments
This review is dedicated to my wife, Hanna. Without her
encouragement, advice, patience, dedication, and support throughout
our 52 years of life together, I would not have been able to accomplish
my part of Doxil development.
I also want to thank my four daughters, Chagit, Ayelet, Tamar,
and Avigail, who grew up during the years described in this review;
their husbands, Uri, Perri, Ron, and Assaf; and last but not least, our
12 grandchildren, Yael, Yuval, Amit, Omri, Inbar, Mika, Rotem, Guy,
Eyal, Gal, Dror, and Kfir, who give us so much joy. Our daughters and
grandchildren were my escape during periods of despair.
Professionally, I would like to thank a few of the many people who
deserve my gratitude: Alberto Gabizon, a 32-year partner in exciting
research including Doxil development, and a friend (the many shared
papers and patents with him are excellent evidence of our highly
productive collaborative interaction) the late Demetrios (Dimitri)
Papahadjopoulos, for his friendship and intellectual stimulus; and
Nick Arvanitidis, from whom I learned about priorities in applied
research and for the many heated disputes we had.
References
Abuchowski, A., McCoy, J.R., Palczuk, N.C., van Es, T., and Davis, F.F., Eff ect
of covalent attachment of polyethylene glycol on immunogenicity and
circulating life of bovine liver catalase, J. Biol. Chem. 252 (11), 3582-
3586 (1977).
Allen, T.M., Liposomes with enhanced circulation time, U.S. Patent 4,837,028
(1989).
Allen, T.M., From fusion to magic bullets: the influence of Dimitri
Papahdjopoulos, J. Liposome Res . 5 , 657-667 (1995).
Allen, T.M., and Chon, A, Large unilamellar liposomes with low uptake by
reticuloendothelial system. FEBS Lett. 223 , 42-46 (1987).
Amselem, S., Cohen, R., Druckmann, S., Gabizon, A., Goren, D., Abra, R.M.,
Huang, A., New, R. and Barenholz, Y., Preparation and characterization
of liposomal doxorubicin for human use. J. Liposome Res . 2 , 93-123
(1992).
Amselem, S., Cohen, R. and Barenholz, Y., 1993a. In vitro tests to predict in
vivo performance of liposomal dosage forms. Chem. Phys. Lipids 64 ,
219-237 (1993a).
 
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