Biomedical Engineering Reference
In-Depth Information
suitable for HCS analysis. Table 9.2 lists the most representative
instruments currently available for image-based HCS and their
type of optics. Their characteristics diff er regarding light source,
the feasibility of carrying out kinetic assays, autofocus technology,
resolution, dynamic range of the camera, and software for analysis,
among several other features. Moreover, almost every brand off ers
its own proprietary algorithms for cell analysis and there are even
companies that also off er kits for developing the assays [4].
Table 9.2
Current commercially available instruments for image based
HCS and their optics
Company
HCS system
Optics
Website
Amnis
ImageStream
Wide
field
www.amnis.com
BD
Biosciences
BD Pathway 855 Wide
Field/
confocal
www.bdbiosciences.com
BD
Biosciences
BD Pathway 435 Wide
Field/
confocal
www.bdbiosciences.com
GE Healthcare IN Cell Analyzer
2000
Wide
field
www.biacore.com
Intelligent
Imaging
Innovations
3i Marianas
Wide
field
www.intelligent-
imaging.com
Leica
Microsystems
TCS SP5
Confocal www.leica-
microsystems.com
Molecular
Devices
ImageXpressULTRA Confocal www.moleculardevices.
com
Molecular
Devices
ImageXpressMICRO Wide
field
www.moleculardevices.
com
Scan
R
Olympus
Wide
field
www.olympus.com
Perkin Elmer Opera
Confocal www.perkinelmer.com
Perkin Elmer Operetta
Wide
Field/
confocal
www.perkinelmer.com
Thermo
Scientific
Cellomics
ArrayScan VTI
Wide
field/
confocal
www.cellomics.com
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