Biomedical Engineering Reference
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Figure 4.2 Molecular targets on tumor cells and on tumor endothelial cells.
See also Color Insert.
Table 4.2 Targeting moieties and their targets
Target
Targeting moiety
Ref.
Integrin α v β 3
RGD motif
[51-55]
Integrin α v β 5
RGD motif
[54, 55]
Aminopeptidase N
(CD13)
NRG motif
[56]
Endothelial
cells
VEGFRs
Pegaptanib
[57]
EGFR
EGFR-peptide
[58]
E-selectin
Ebsp, Synthetic analog
of sLex
[59, 60]
HA receptor/CD44 HA
[61]
Folate receptor Folic acid [62-67]
TfR Transferrin [6, 68, 69]
LHRH receptor LHRH analog peptide [70-73]
HA receptor/CD44 HA [61]
MSH receptor MSH [74]
Hepatocyte ASGR Galactosamine [75, 76]
CEA Anti CEA half-antibody [77]
EGFR: epidermal growth factor receptor; Ebsp: E-selectin-binding-peptide; HA:
hyaluronic Acid; TfR: Transferrin receptor; LHRH: Luteinizing hormone-releasing
hormone; MSH: melanocyte-stimulating hormone; ASGR: asialoglycoprotein receptor;
CEA: Carcinoembryonic antigen.
Tumor cells
 
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